Show Notes EP 532 Dom D’Agostino

  • Does he have any monetary drive with the research he is doing? (3:51)
    • Develop business model to compete with speed of market
      • Educate
      • Speak to distributors
      • Company would pay for that
    • Make claims need to put pocket book where mouth is
  • What are some of the crazy claims he is seeing now? (9:24)
    • It’s the supplement and not the diet (ketogenic) that is working
  • Traumatic brain injury and being on the ketogenic diet (14:36)
    • Glucose pet scan
    • Ketones have anti-inflammatory markers
    • Dysregulation of transporters at the brain
      • PHD complex
  • Why do some people seem to do better on the keto diet? (17:50)
    • Less carb tolerant
    • Predict diet that may be optimal for us
    • Listen to your body/signals
  • The average healthy person, what can the keto diet do for them? (21:38)
    • Not for the average person
    • Modified Atkins diet would work best
  • When does the switch happen with relation to becoming less carb tolerant? 
    • Activity level
    • Hormone level
    • Mitochondria decreases with age
    • High fat intake will increase mitochondrial
    • Train body to burn fat using ketones
    • Body works better with relative changes
  • What advice would he give to younger generation regarding their eating habits? (29:34)
    • Analyze their activity level
      • What they are putting into their body
    • May need nutritional psychotherapist
    • Controlling appetite
  • Why does one lose so much weight while on the ketogenic diet? (36:54)
    • Increase protein around workouts
      • Keep carb/fat ratio the same
  • Exogenous ketones discussion (38:05)
    • Navy Seals training
    • Very underreported
    • Energy molecule you can consume to fuel your body
    • Ketones are the next creatine
    • Beta-hydroxybutyrate supplement
    • Using ketones to build muscle
  • His current research and what he is working on now? (51:54)
    • Oxygen toxicity seizures
      • Department of Defense
        • NAVY
      • Duke University
    • Exercise performance
      •  Warfighter performance
      • Hypothermia
  • Do we see individual variances with people on ketogenic diet? (58:04)
    • Tools to measure ketones
    • Performance and how you feel
    • Feel best
      • Measure glucose/insulin levels
    • Composition of the fats consumed
      • Monounsaturated fat
  • How does he make a living being a scientist/researcher? (1:10:29)
    • Expensive to take on PhD student
      • Pay tuition, etc.
    • Keep writing grants to get your own funding
    • Kept grinding to get additional funding
      • Always on edge
      • Salary is set
    • 10 year track position
      • Metric you have to hit within 5 year time frame
      • Promoted to 10 year
        • School covers your salary
        • Secures position at school
    • School owns intellectual property
  • Does going on podcasts help with funding? (1:18:00)
    • Reaches larger platform
    • Doing research people are interested in
  • Does he battle with leaving academia and going on his own? (1:20:47)
    • Put in so much time and effort to get where he is
    • Science has to get out there
    • Has students working in lab
    • A lot of paperwork
    • A donor likes what he is doing to gives him funding
    • Technical reports
      • Office of NAVAL research
      • Present work to organization
  • What exercises/things does he do to detach from work? 
    • Takes dogs out every night
    • Get on his motorcycle, go to gym and workout
    • Have opportunities to travel the world
      • Take one day to walk around and explore
  • Who are some of his favorite people he has got to come across? (1:27:12)
  • Final thoughts on ketones / intermittent fasting (1:35:39)
    • He fasts 2-3 times a week
    • Any research on metabolism
    • Effects of ketones of anxiety behavior
      • Elevated pulse maze

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